All of these abnormalities were prevented or markedly diminished by partial or complete genetic removal of tau. Similar to a proportion of people with autism, both models have epilepsy, abnormally enlarged brains, and overactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B)/ mammalian target of rapamycin (mTOR) signaling pathway. Here, we show that genetically reducing the protein tau prevents behavioral signs of autism in two mouse models simulating distinct causes of this condition. It is a prevalent neurodevelopmental disorder, and available treatments offer little benefit. Autism is characterized by repetitive behaviors, impaired social interactions, and communication deficits.
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